This observation is in line with (a) decreased plasma GSH levels in women who underwent surgical menopause (Kaur et al., 2017), and (b) decreased serum tGSH levels in post- relative to pre-menopausal women (Ramrez-Expsito et al., 2014)
Nano-Structured Lipid Carrier-Based Oral Glutathione Formulation Mediates Renoprotection Against Cyclophosphamide-Induced Nephrotoxicity, and Improves Oral Bioavailability of Glutathione Confirmed through RP-HPLC Micellar Liquid Chromatography
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10.1016/0006-2952(89)90184-6 Biochem
Prolonged intake of high doses may occasionally lead to thyroid dysfunction or low zinc levels in the body
Within the cell, it exists mainly (98%) in the thiol-reduced form (GSH), but some are also present as glutathione disulfide (GSSG)